Fibrates stimulate cellular fatty acid uptake, conversion to acyl-CoA derivatives, and catabolism by the β-oxidation pathways, which, combined with a reduction in fatty acid and triglyceride synthesis, results in a decrease in VLDL production. Fibrates lower hepatic apoC-III production and increase lipoprotein lipase-mediated lipolysis via PPAR. The PPAR-α form mediates fibrate action on HDL cholesterol levels via transcriptional induction of synthesis of the major HDL apolipoproteins, apoA-I and apoA-II. Fibrates activate specific transcription factors belonging to the nuclear hormone receptor superfamily, termed peroxisome proliferator-activated receptors (PPARs). Recent investigations indicate that the effects of fibrates are mediated, at least in part, through alterations in transcription of genes encoding for proteins that control lipoprotein metabolism. Customer Service and Ordering InformationĪbstract-Treatment with fibrates, a widely used class of lipid-modifying agents, results in a substantial decrease in plasma triglycerides and is usually associated with a moderate decrease in LDL cholesterol and an increase in HDL cholesterol concentrations.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).Happiness and sadness, heroes and heroines, and the final happy ending. A love that comes through the pages and touches your heartstrings ' ' is written with deep feeling for its two main characters. What readers are saying about Rainbow Days : Separated, each is swept along to a place where there is no love or peace and no way back. As a dutiful son, Silas has no choice but to obey his father, and Cathleen must pay the bitter price. Throughout their childhood their love has grown stronger and now, in 1900, they start to plan a life together.īut a jealous woman is determined to ruin their happiness and uses Silas's father - a good and honest man - to do so, forcing him to make an impossible sacrifice. I'd have to lose my life before I'd lose you.' This is the vow Silas made to Cathleen on the day he asks her to marry him. Perfect for fans of Kitty Neale and Cathy Sharp. In Rainbow Days, Josephine Cox writes a compelling saga exploring the strength of love, and the obstacles that can cause its destruction. Bitter jealousies threaten the happiness of two people forever.
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